Choroidal neovascularization silent on optical coherence tomography: report of two cases.

Herein, we report two cases of vision loss after successful cataract surgery, associated with drusenoid retinal pigment epithelial detachment without features of choroidal neovascularization on optical coherence tomography along with angiographic examinations suggestive of choroidal neovascularization in which anatomical and functional improvements were achieved with intravitreal injections of anti-vascular endothelial growth factor.

Choroidal neovascularization silent on optical coherence tomography: report of two cases / Neovascularização de coroide silente a tomografia de coerência ótica: relato de dois casos

ABSTRACT Herein, we report two cases of vision loss after successful cataract surgery, associated with drusenoid retinal pigment epithelial detachment without features of choroidal neovascularization on optical coherence tomography along with angiographic examinations suggestive of choroidal neovascularization in which anatomical and functional improvements were achieved with intravitreal injections of anti-vascular endothelial growth factor.

RESUMO Relatamos dois casos de baixa visual após cirurgia bem sucedida de catarata, associada a descolamento drusenóide do epitélio pigmentar da retina (DPED) sem achados de neovascularização de coroide a tomografia de coerência óptica OCT (CNV silente ao OCT) e com exames angiográficos sugestivos de neovascularização da coroide (CNV), nos quais melhoras anatômicas e funcionais foram obtidas com aplicações intravítreas de anti-VEGF.

Orbital invasion by squamous cell carcinoma arising in multiple epidermoid cysts.

Epidermal or epidermoid cysts usually are benign, solitary-growing masses located in the mid- or lower dermis. They are believed to derive from pilosebaceous units and are lined with an epidermis-like epithelium including a granular cell layer. The occurrence of multiple epidermal cysts on the scalp of nonsyndromic patients is extremely rare. Although the presence of squamous cell carcinoma in the wall of an isolated epidermoid cysts is well documented in the dermatological literature,, the authors are not aware of any article in the English literature describing orbital invasion by a carcinoma developed in isolated or multiple epidermoid cysts.

Distribution of spontaneous inter-blink interval in repeated measurements with and without topical ocular anesthesia.

PURPOSE: To determine if the distribution of inter-blink time intervals is constant with repeated measurements with and without topical ocular anesthesia. METHODS: Inter-blink time was measured in 15 normal subjects ranging from 19 to 32 years (mean ± SD= 23.9 ± 3.20) with the magnetic search coil technique on 3 different occasions, the last one with topical ocular anesthesia. RESULTS: One-way analysis of variance for repeated measurements showed that topical anesthesia significantly reduced the blink rate (blinks per minute), which was constant in the first two measurements (F=8.27, p=0.0015. First measurement: mean ± SD= 13.7 ± 7.8; second measurement: 13.1 ± 8.5 SD; with topical anesthesia: = 7.2 ± 4.6). However, distributions shape was not affected when the blink rate was reduced. The three distributions followed a Log Normal pattern, which means that the time interval between blinks was symmetrical when the time logarithm was considered. CONCLUSIONS: Topical ocular anesthesia reduces the rate of spontaneous blinking, but does not change the distribution of inter-blink time interval.

Distribution of spontaneous inter-blink interval in repeated measurements with and without topical ocular anesthesia / Distribuição dos intervalos do piscar espontâneo em medidas repetidas com e sem anestesia tópica ocular

PURPOSE: To determine if the distribution of inter-blink time intervals is constant with repeated measurements with and without topical ocular anesthesia. METHODS: Inter-blink time was measured in 15 normal subjects ranging from 19 to 32 years (mean ± SD= 23.9 ± 3.20) with the magnetic search coil technique on 3 different occasions, the last one with topical ocular anesthesia. RESULTS: One-way analysis of variance for repeated measurements showed that topical anesthesia significantly reduced the blink rate (blinks per minute), which was constant in the first two measurements (F=8.27, p=0.0015. First measurement: mean ± SD= 13.7 ± 7.8; second measurement: 13.1 ± 8.5 SD; with topical anesthesia: = 7.2 ± 4.6). However, distributions shape was not affected when the blink rate was reduced. The three distributions followed a Log Normal pattern, which means that the time interval between blinks was symmetrical when the time logarithm was considered. CONCLUSIONS: Topical ocular anesthesia reduces the rate of spontaneous blinking, but does not change the distribution of inter-blink time interval.

OBJETIVOS: Determinar se a distribuição dos intervalos do piscar espontâneo se mantém em medidas repetidas com e sem anesthesia tópica ocular. MÉTODOS: Os intervalos entre movimentos de piscar da pálpebra superior foram medidos com rastreamento magnético (Magnetic Search Coil) em 15 sujeitos (11 do sexo masculino) normais com idades entre 19 a 32 anos (média 23,86 ± 3,20 dp anos). RESULTADOS: Análise de variância unifatorial para medidas repetidas mostrou que a anesthesia tópica ocular diminuiu significativamente a frequência média (número de blinks/minuto) do piscar espontâneo, a qual se manteve constante nas duas primeiras medidas (F=8,27, p=0,0015. Primeira medida 13,7 ± 7,8 DP; segunda medida 13,1 ± 8,5; com anestesia tópica 7,2 ± 4,6). No entanto, a forma da distribuição nas 3 medidas obedeceu uma distribuição do tipo Log Normal, de modo que os intervalos de piscar foram normalmente distribuídos quando o logaritmo do intervalo foi considerado. CONCLUSÕES: A anesthesia tópica ocular diminui significativamente a frequência de piscar, mas não altera a distribuição dos intervalos do piscar espontâneo.